The Mexicans scored two goals in four minutes to record the lead in the game played at the 77,500- capacity LA Coliseum on Sunday (Nigerian time).
The match is one of the most-attended games globally since the restrictions that followed the coronavirus pandemic which broke out last year.
Hector Herrera put the Mexicans in front in the 2nd minute from the first corner kick of the match while Rogelio Funes Mori made it 2-0 in the fourth minute, Udo kept him on-side as the referee awarded the goal despite calls for offside by the Nigerians.
Luis Rodriguez was shown a yellow card in the 14th minute for a foul on Anayo Iwuala. He halted the Nigerian who was headed for a fast counterattack.
Jesus Corona almost made it 3-0 in the 25th minute but his volley from an accurate Hirving Lozano’s cross flew over the bar.
Lozano saw his shot saved by Nwabali in the 29th minute and went close once again in the 30th minute but his shot went wide this time.
Eagles failed to get a shot on or off-target in the first 45 minutes as the Mexicans controlled the tempo of the game.
The Eagles defender, Imo Udo was booked in the 53d minute for a foul on Mexican forward Lozano after a dangerous tackle on the right flank but Nwabali makes a smart save from the resulting free-kick after skipper Herrera jumped the highest to head the ball.
Olusesi did well to stop Lozano’s cross at the start of the second half. The Napoli star called Nigeria’s goalkeeper into a smart save after blasting a shot from 22 yards. Nwabali was also up to the task to save a close-range header from the resulting corner kick.
Nwabali was beaten the third time by Mexican skipper Herrera. The Atletico Madrid midfielder scored his brace after benefiting from a loose ball from Nwabali’s save from a Lozano attempt on goal.
Stephen Jude and Sunday Adetunji came on for Seth Mayi and Charles Atshimene in the 58 minutes of the encounter.
Franklin Tebo replaced Adekunle Adeleke while injured Uche Onwuasoanya came off for Rabiu Zilkiflu in the 67th minute.
Jonathan dos Santos made it 4-0 in the 78th minute scoring from Erick Gutierrez’s well-calculated pass from the midfield.